The origins of the 53e Ligne date back to the Regiment Alsace, first raised in 1656.
It spent 1805 - 1806 as part of the Army of Italy (fighting at Caldiero, Tagliamento, and in the Tyrol).
1808 - 1809 the Regiment was once again with the Army of Italy ( Battle on the Piave, Tagliamento, San Michele, Raab, Wagram, and Znaim).
The regiment was part of the invasion of Russia in 1812, and fought at Borodino, Maloyaroslavets, and Krasnoe.
In 1813 - 1814, it returned again to the Army of Italy, where it was engaged at Caldiero, San Michele, Boara, and the Mincio.